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Chemical Structure : LY-404039
CAS No.: 635318-11-5
Catalog No.: PC-45900Not For Human Use, Lab Use Only.
A potent, slective agonist of mGlu2 and mGlu3 receptors with Ki of 149 nM and 92 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $80 | In stock | |
| 50 mg | $288 | In stock |
Bulk size, bulk discount!
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A potent, slective agonist of mGlu2 and mGlu3 receptors with Ki of 149 nM and 92 nM, respectively; displays >100-fold selectivity over other ionotropic glutamate receptors, glutamate transporters; suppresses electrically evoked excitatory activity in the striatum, and serotonin-induced l-glutamate release in the prefrontal cortex; reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats; oral bioavailable.
Schizophrenia
Phase 1 Clinical
| M.Wt | 235.2145 | |
| Formula | C7H9NO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO:1 mg/mL;H2O:< 1 mg/mL |
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| Chemical Name/SMILES |
2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, 4-amino-, 2,2-dioxide, (1R,4S,5S,6S)- |
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1. Rorick-Kehn LM, et al. J Pharmacol Exp Ther. 2007 Apr;321(1):308-17.
2. Rodd ZA, et al. Behav Brain Res. 2006 Aug 10;171(2):207-15.
3. Patil ST, et al. Nat Med. 2007 Sep;13(9):1102-7.
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