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Chemical Structure : LY2940680
CAS No.: 1258861-20-9
Catalog No.: PC-43422Not For Human Use, Lab Use Only.
LY2940680 (Taladegib) is potent Smoothened (SMO) receptor antagonist, potently inhibits Hedgehog (Hh) signaling with IC50 of 6.3 nM in Gli-luc reporter assyas.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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LY2940680 (Taladegib) is potent Smoothened (SMO) receptor antagonist, potently inhibits Hedgehog (Hh) signaling with IC50 of 6.3 nM in Gli-luc reporter assyas.
LY2940680 (Taladegib) inhibits medulloblastoma cell proliferation isolated from Ptch+/–p53–/– mice with IC50 of 43.5 nM.
LY2940680 (Taladegib) demonstrates anti-tumor activity in vivo with advanced basal cell carcinoma (BCC) and other malignancies.
| M.Wt | 512.502 | |
| Formula | C26H24F4N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 5.2 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)- |
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1. Wang C, et al. Nature. 2013 May 16;497(7449):338-43.
2. Lauressergues E, et al. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214.
3. Jin G, et al. Arch Pharm Res. 2017 Dec;40(12):1390-1393.
4. Lu X, et al. Eur J Med Chem. 2017 Sep 29;138:384-395.
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