You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-ASBT Transporter (SLC10A2)-Linerixibat
Linerixibat

Chemical Structure : Linerixibat

CAS No.: 1345982-69-5

Linerixibat (GSK-2330672;GSK2330672)

Catalog No.: PC-61384Not For Human Use, Lab Use Only.

Linerixibat (GSK2330672) is a highly potent, selective, ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor with IC50 of 2.1/1.9 nM for mouse/rat ASBT, respectively.

Packing Price Stock Quantity
5 mg $238 In stock
10 mg $378 In stock
25 mg $588 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Linerixibat (GSK2330672) is a highly potent, selective, ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor with IC50 of 2.1/1.9 nM for mouse/rat ASBT, respectively.
Linerixibat (GSK2330672 lowers glucose in an animal model of type 2 diabetes, shows excellent developability properties for evaluating the potential therapeutic utility of a nonabsorbable ASBT inhibitor for treatment of patients with type 2 diabetes.

Physicochemical Properties

M.Wt 546.679
Formula C28H38N2O7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[[[(3R,5R)-3-Butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl]methyl]amino]pentanedioic acid

References

1. Wu Y, et al. J Med Chem. 2013 Jun 27;56(12):5094-114.

2. Nunez DJ, et al. Diabetes Obes Metab. 2016 Jul;18(7):654-62.

3. Hegade VS, et al. Lancet. 2017 Mar 18;389(10074):1114-1123.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: