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Chemical Structure : Linsitinib
CAS No.: 867160-71-2
Catalog No.: PC-42436Not For Human Use, Lab Use Only.
Linsitinib (ASP-7487, OSI-906) is a potent, selective, orally active, dual IGF-1R/insulin receptor inhibitor with IC50 of 35/75 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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Linsitinib (ASP-7487, OSI-906) is a potent, selective, orally active, dual IGF-1R/insulin receptor inhibitor with IC50 of 35/75 nM, respectively.
Linsitinib (ASP-7487, OSI-906) potently and selectively inhibits autophosphorylation of both human IGF-1R and IR, displays in vitro antiproliferative effects in a variety of tumor cell lines.
Linsitinib (ASP-7487, OSI-906) shows robust in vivo anti-tumor efficacy in an IGF-1R-driven xenograft model.
| M.Wt | 421.4937 | |
| Formula | C26H23N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Cyclobutanol, 3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-, cis- |
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1. Mulvihill MJ, et al. Future Med Chem. 2009 Sep;1(6):1153-71.
2. Pitts TM, et al. Clin Cancer Res. 2010 Jun 15;16(12):3193-204.
3. Buck E, et al. Mol Cancer Ther. 2010 Oct;9(10):2652-64.
4. Kuhn DJ, et al. Blood. 2012 Oct 18;120(16):3260-70.
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