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Chemical Structure : MAP4K4-IN-37
Catalog No.: PC-35005Not For Human Use, Lab Use Only.
MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM.
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MAP4K4-IN-37 is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM.
MAP4K4-IN-37 inhibits the other kinase family members, MINK and TNIK (IC50 of 1.3 and <0.6 nM).
MAP4K4-IN-37 possesses a high degree of kinome selectivity against a set of 244 kinases.
MAP4K4-IN-37 shows potent cellular potency with IC50 of 222 nM, exhibits substantial suppression of TNFα release on LPS-induced TNFα levels in male C57-BL/6J mice
| M.Wt | 382.844 | |
| Formula | C21H19ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dow RL, et al. J Med Chem. 2018 Apr 12;61(7):3114-3125.
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