Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MCC950
CAS No.: 210826-40-7
Catalog No.: PC-43228Not For Human Use, Lab Use Only.
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $358 | In stock | |
| 200 mg | Get quote | ||
| 1 | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3.
MCC950 blocks NLRP3 induced ASC oligomerization, does not block K+ efflux, Ca2+ flux or NLRP3-ASC interactions; reduces interleukin-1β (IL-1β) production in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (EAE).
MCC950 rescues neonatal lethality in mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome.
| M.Wt | 404.4799 | |
| Formula | C20H24N2O5S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 28 mg/mL |
|
| Chemical Name/SMILES |
2-Furansulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)- |
|
1. Coll RC, et al. Nat Med. 2015 Mar;21(3):248-55.
2. Krishnan SM, et al. Br J Pharmacol. 2016 Feb;173(4):752-65.
3. Baker PJ, et al. Eur J Immunol. 2015 Oct;45(10):2918-26.
4. Primiano MJ, et al. J Immunol. 2016 Sep 15;197(6):2421-33.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
