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Chemical Structure : MFA-1
Catalog No.: PC-63021Not For Human Use, Lab Use Only.
MFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays, displays 500-fold more potent than CDCA.
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MFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays, displays 500-fold more potent than CDCA.
MFA-1 displays an unexpected mode of binding and activation to FXR.
| M.Wt | 420.549 | |
| Formula | C27H32O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Soisson SM, et al. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5337-42.
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