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Chemical Structure : MK-0941
CAS No.: 752240-01-0
Catalog No.: PC-61878Not For Human Use, Lab Use Only.
MK-0941 (MK0941) is a novel potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $688 | In stock | |
| 1 g | Get quote |
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MK-0941 (MK0941) is a novel potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively; increases insulin secretion by 17-fold and glucose uptake up to 18-fold, respectively, in isolated rat islets of Langerhans and hepatocytes at 10 uM; exhibits strong glucose-lowering activity in rodent models of type 2 diabetes and healthy dogs.
Diabetes
Phase 2 Discontinued
| M.Wt | 460.5 | |
| Formula | C21H24N4O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[[6-(ethylsulfonyl)-3-pyridinyl]oxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide |
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1. Eiki J, et al. Mol Pharmacol. 2011 Dec;80(6):1156-65.
2. Meininger GE, et al. Diabetes Care. 2011 Dec;34(12):2560-6.
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