Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MK-3281
Catalog No.: PC-63573Not For Human Use, Lab Use Only.
MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM; MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons, shows 2 orders of magnitude less active on 2a (EC50=2018 nM) and 2b (EC50=1833 nM) replicons; demonstrates consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection.
HCV Infection
Phase 1 Discontinued
| M.Wt | 475.633 | |
| Formula | C29H37N3O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Narjes F, et al. J Med Chem. 2011 Jan 13;54(1):289-301.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
