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Chemical Structure : MK-3697
CAS No.: 1224846-01-8
Catalog No.: PC-42964Not For Human Use, Lab Use Only.
MK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM, shows exquisite selectivity over OX1R (Ki=18 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 25 mg | $348 | In stock | |
| 100 mg | $958 | In stock | |
| 500 mg | Get quote |
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MK-3697 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki of 1.1 nM and IC50 of 16 nM, shows exquisite selectivity over OX1R (Ki=18 uM); MK-3697 is orally efficacious in sleep experiments across species with high OX2R occupancy and low OX1R blockade, demonstrated excellent sleep efficacy across species, and shows potential for the treatment of insomnia.
Sleep Disorder
Phase 2 Discontinued
| M.Wt | 447.5096 | |
| Formula | C23H21N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 22.5 mg/mL |
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| Chemical Name/SMILES |
[2,3'-Bipyridine]-4-carboxamide, N-[(5,6-dimethoxy-2-pyridinyl)methyl]-5'-methyl-5-(2-thiazolyl)- |
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1. Roecker AJ, et al. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4884-90.
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