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Chemical Structure : MK-8591
CAS No.: 865363-93-5
Catalog No.: PC-61817Not For Human Use, Lab Use Only.
MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs, inhibits HIV-1 reverse transcriptase with multiple mechanisms.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $458 | In stock | |
| 100 mg | Get quote |
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MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs, inhibits HIV-1 reverse transcriptase with multiple mechanisms.
MK-8591 also retains potent activity against multinucleoside-resistant HIV-2 mutants (EC50<11 nM).
| M.Wt | 293.25 | |
| Formula | C12H12FN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol |
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1. Wu VH, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00744-17.
2. Salie ZL, et al. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9274-9.
3. Michailidis E, et al. J Biol Chem. 2014 Aug 29;289(35):24533-48.
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