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Chemical Structure : MK2-IN-28
Catalog No.: PC-70144Not For Human Use, Lab Use Only.
MK2-IN-28 is a potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM.
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MK2-IN-28 is a potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM. MK2-IN-28 inhibits both MK2 and MK3, and has no or little effect on the other kinases.
MK2-IN-28 ameliorates glucose homeostasis by suppressing excessive HGP and enhancing insulin signaling in obese mice.
| M.Wt | 569.665 | |
| Formula | C35H31N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.
2. Ozcan L, et al. Diabetes. 2015 Oct;64(10):3396-405.
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