Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MK 2206 dihydrochloride
CAS No.: 1032350-13-2
Catalog No.: PC-42551Not For Human Use, Lab Use Only.
MK 2206 dihydrochloride is a potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MK 2206 dihydrochloride is a potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.
MK 2206 shows 5-fold less potent against human Akt3 (IC50=65 nM).
MK 2206 synergistically inhibits cell proliferation of human cancer cell lines in combination with erlotinib or lapatinib in vitro.
MK 2206 suppresses the Akt phosphorylation that is induced by carboplatin and gemcitabine.
| M.Wt | 480.389 | |
| Formula | C25H23Cl2N5O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO |
|
| Chemical Name/SMILES |
1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-, hydrochloride (1:2) |
|
1. Hirai H, et al. Mol Cancer Ther. 2010 Jul;9(7):1956-67.
2. Cheng Y, et al. Mol Cancer Ther. 2012 Jan;11(1):154-64.
3. Whicker ME, et al. BMC Cancer. 2016 Jul 27;16:550.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
