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ML132

Chemical Structure : ML132

CAS No.: 1230628-71-3

ML132 (NCGC-00183434;CID-4462093)

Catalog No.: PC-63279Not For Human Use, Lab Use Only.

ML132 (NCGC-00183434, CID-4462093) is a highly potent, selective Caspase 1 inhibitor with IC50 of 0.023 nM, displays >1,000-fold selectivity over a panel of 9 caspases..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML132 (NCGC-00183434, CID-4462093) is a highly potent, selective Caspase 1 inhibitor with IC50 of 0.023 nM, displays >1,000-fold selectivity over a panel of 9 caspases.

Physicochemical Properties

M.Wt 477.941
Formula C22H28ClN5O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-3-((S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-cyanopropanoic acid

References

1. Boxer MB, et al. A small molecule inhibitor of Caspase 1. Probe Reports from the NIH Molecular Libraries Program [Internet].

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