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Chemical Structure : ML216
CAS No.: 1430213-30-1
Catalog No.: PC-42991Not For Human Use, Lab Use Only.
ML216 (CID49852229) is a potent, selective inhibitor of DNA unwinding activity of BLM (Bloom's syndrome protein) with IC50 of 2.98 and 0.97 uM for full length BLM and BLM636-1298, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ML216 (CID49852229) is a potent, selective inhibitor of DNA unwinding activity of BLM (Bloom's syndrome protein) with IC50 of 2.98 and 0.97 uM for full length BLM and BLM636-1298, respectively.
ML216 weak inhibits WRN helicase (IC50=12.6 uM) and does not inhibit RecQ1, RecQ5 and UrvD (IC50>50 uM).
ML216 disrupts BLM’s binding to DNA, rather than being an inhibitor of ATP binding by BLM, the inhibition of ssDNA-dependent ATPase activity with Ki of 1.76 uM,.
ML216 shows cell-based activity and can induce sister chromatid exchanges, enhances the toxicity of aphidicolin, and exerts antiproliferative activity in cells expressing BLM.
| M.Wt | 383.3235 | |
| Formula | C15H9F4N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 1.71 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]- |
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1. Nguyen GH, et al. Chem Biol. 2013 Jan 24;20(1):55-62.
2. Rosenthal AS, et al. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5660-6.
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