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Chemical Structure : ML 604086
CAS No.: 850330-18-6
Catalog No.: PC-61979Not For Human Use, Lab Use Only.
ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3 uM and 1.0 uM respectively in cellular assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3 uM and 1.0 uM respectively in cellular assays.
ML 604086 displays high selectvity against a panel of 40 GPCRs, only moderately inhibits 5HT1a (30% at 10 uM).
| M.Wt | 508.637 | |
| Formula | C27H32N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[4-[[[(3R,4R)-1-[(2S)-2-Amino-1-oxopropyl]-3-methyl-4-piperidinyl]amino]sulfonyl]-1-naphthalenyl]-2-methylbenzamide |
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1. Jenkins TJ, et al. J Med Chem. 2007 Feb 8;50(3):566-84.
2. Wang L, et al. Thorax. 2013 Jun;68(6):506-12.
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