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MRL-1237

Chemical Structure : MRL-1237

CAS No.: 276704-21-3

MRL-1237 (MRL1237)

Catalog No.: PC-62926Not For Human Use, Lab Use Only.

MRL-1237 is a potent and selective inhibitor of the replication of Enteroviruses with EC50 of 1-10 uM, targets the nonstructural 2C protein.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MRL-1237 is a potent and selective inhibitor of the replication of Enteroviruses with EC50 of 1-10 uM, targets the nonstructural 2C protein; inhibits poliovirus-specific RNA synthesis in HeLa cells infected with a wild strain but not with an F164Y mutant.

Physicochemical Properties

M.Wt 354.813
Formula C19H16ClFN4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-((1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-yl)methyl)pyridin-4(1H)-imine hydrochloride

References

1. Shimizu H, et al. J Virol. 2000 May;74(9):4146-54.

2. De Palma AM, et al. J Virol. 2008 May;82(10):4720-30.

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