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MRT-68921 hydrochloride

Chemical Structure : MRT-68921 hydrochloride

CAS No.: 2080306-21-2

MRT-68921 hydrochloride (MRT 68921 hydrochloride;MRT68921 hydrochloride)

Catalog No.: PC-42021Not For Human Use, Lab Use Only.

MRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.

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25 mg $160 In stock
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100 mg $376 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
MRT-68921 hydrochloride inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK; reduces phospho-ATG13 and blocks autophagy in cells.

Physicochemical Properties

M.Wt 471.038
Formula C25H35ClN6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: 10 mg/mL

Chemical Name/SMILES

Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-,hydrochloride (1:2)

References

1. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.

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