Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MRT 199665
Catalog No.: PC-61765Not For Human Use, Lab Use Only.
MRT 199665 is a potent salt-inducible kinases (SIKs) inhibitor with IC50 of 110, 12, 43 nM for SIK1,2,3 respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MRT 199665 is a potent salt-inducible kinases (SIKs) inhibitor with IC50 of 110, 12, 43 nM for SIK1,2,3 respectively.
MRT 199665 also inhibits AMPKα1/α2 (both IC50=10 nM), MARK1/2/3/4 (both IC50=2 nM), NUAK1/2 (IC50=3/120 nM), and MELK (IC50=29 nM).
MRT 199665 elevates IL-10 production by inducing the dephosphorylation of CREB-regulated transcriptional coactivator 3 (CRTC3), increases LPS-stimulated IL-10 production and greatly suppressed proinflammatory cytokine secretion (IL-6, IL-12, and TNF) in macrophages.
| M.Wt | 373.43 | |
| Formula | C18H19N3O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Clark K, et al. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91.
2. Darling NJ, et al. Biochem J. 2017 Feb 15;474(4):521-537.
3. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
