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Chemical Structure : MYC inhibitor DC-34
Catalog No.: PC-35731Not For Human Use, Lab Use Only.
MYC inhibitor DC-34 is a potent small molecule that selectively inhibits MYC at the transcriptional level only when a G-quadruplex (G4) is present in the promoter, binds to MYC G4 with Kd of 9.4 uM.
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MYC inhibitor DC-34 is a potent small molecule that selectively inhibits MYC at the transcriptional level only when a G-quadruplex (G4) is present in the promoter, binds to MYC G4 with Kd of 9.4 uM; does not transcriptionally downregulate several other G4-dependent genes to the same extent; binds independently to the MYC G4 3'and 5' ends, demonstrates cytotoxicity in L363 MM cells with IC50 of 3.5 uM.
| M.Wt | 446.47 | |
| Formula | C24H25F3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Calabrese DR, et al. Nat Commun. 2018 Oct 12;9(1):4229.
2. Felsenstein KM, et al. ACS Chem Biol. 2016 Jan 15;11(1):139-48.
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