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Chemical Structure : Melflufen
Catalog No.: PC-60562Not For Human Use, Lab Use Only.
Melflufen (Melphalan flufenamide, J1) is a novel dipeptide and alkylating prodrug of melphalan, inhibits angiogenesis in vitro and in vivo.
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Melflufen (Melphalan flufenamide, J1) is a novel dipeptide and alkylating prodrug of melphalan, inhibits angiogenesis in vitro and in vivo; shows cytotoxic activity against lymphoma cell lines with IC50 of 0.011-0.92 uM, also shows significantly lower IC50 than melphalan in multiple myeloma cells; induces apoptosis even in melphalan- and bortezomib-resistant multiple myeloma cells.
Blood Cancer
Phase 3 Clinical
| M.Wt | 498.42 | |
| Formula | C24H30Cl2FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wickström M, et al. Oncotarget. 2017 Jun 8;8(39):66641-66655.
2. Carlier C, et al. Oncotarget. 2016 Sep 13;7(37):59322-59335.
3. Delforoush M, et al. BMC Cancer. 2016 Apr 4;16:263.
4. Chauhan D, et al. Clin Cancer Res. 2013 Jun 1;19(11):3019-31.
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