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Mertansine

Chemical Structure : Mertansine

CAS No.: 139504-50-0

Mertansine (DM1;Maytansinoid DM1;DM-1;Maytansinoid DM-1;DM 1;Maytansinoid DM 1)

Catalog No.: PC-45714Not For Human Use, Lab Use Only.

Mertansine (DM1) is a tubulin inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Mertansine (DM1) is a tubulin inhibitor; thiol-containing maytansinoid that create an antibody-drug conjugate (ADC); an ADC payload.

Physicochemical Properties

M.Wt 738.2877
Formula C35H48ClN3O10S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 83.33 mg/mL

Chemical Name/SMILES

Maytansine, N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-

References

1. Niculescu-Duvaz I. Curr Opin Mol Ther. 2010 Jun;12(3):350-60.

2. Lambert JM. Br J Clin Pharmacol. 2013 Aug;76(2):248-62.

3. Helft PR, et al. Clin Cancer Res. 2004 Jul 1;10(13):4363-8.

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