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Chemical Structure : NAcM-COV
Catalog No.: PC-61932Not For Human Use, Lab Use Only.
NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays.
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NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays.
NAcM-COV shows highly selectivity with respect to other protein acetyl-amide-binding sites.
NAcM-COV inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.
| M.Wt | 516.609 | |
| Formula | C28H35F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Scott DC, et al. Nat Chem Biol. 2017 Aug;13(8):850-857.
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