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Chemical Structure : NCT-506
Catalog No.: PC-35127Not For Human Use, Lab Use Only.
NCT-506 (NCT506) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.
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NCT-506 (NCT506) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.
NCT-506 also exhibits IC50 of 77 nM in MIA PaCa-2 Aldefluor cell-based assays.
NCT-506 demonstrates target engagement in CETSA asssay (EC50=5.59 uM), inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line.
| M.Wt | 478.54 | |
| Formula | C25H23FN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yang SM, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00270.
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