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NCT-507

Chemical Structure : NCT-507

CAS No.: 2231081-18-6

NCT-507 (NCT507)

Catalog No.: PC-35128Not For Human Use, Lab Use Only.

NCT-507 (NCT507) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.

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    Biological Activity

    NCT-507 (NCT507) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases.
    NCT-507 also exhibits IC50 of 53 nM in MIA PaCa-2 Aldefluor cell-based assays.
    NCT-507 demonstrates target engagement in CETSA asssays, inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line.

    Physicochemical Properties

    M.Wt 494.994
    Formula C25H23ClN4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(4-(6-chloro-3-(4-(methylsulfonyl)piperazine-1-carbonyl)quinolin-4-yl)phenyl)cyclopropane-1-carbonitrile

    References

    1. Yang SM, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00270.

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