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Chemical Structure : NSC-319726
CAS No.: 71555-25-4
Catalog No.: PC-45497Not For Human Use, Lab Use Only.
NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $96 | In stock | |
| 50 mg | $448 | In stock | |
| 500 mg | Get quote |
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NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator; restores WT structure and function to the p53(R175) mutant; kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.
| M.Wt | 234.3207 | |
| Formula | C11H14N4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 27.5 mg/mL |
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| Chemical Name/SMILES |
1-Azetidinecarbothioic acid, 2-[1-(2-pyridinyl)ethylidene]hydrazide |
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1. Yu X, et al. Cancer Cell. 2012 May 15;21(5):614-25.
2. Yu X, et al. Oncotarget. 2014 Oct 15;5(19):8879-92.
3. Yu X, et al. Mol Pharmacol. 2017 Jun;91(6):567-575.
4. Shimada K, et al. Cell Chem Biol. 2018 May 17;25(5):585-594.e7.
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