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Chemical Structure : NSC 668036
CAS No.: 144678-63-7
Catalog No.: PC-61785Not For Human Use, Lab Use Only.
NSC 668036 is a specific inhibitor of the Dishevelled (Dvl) PDZ domain, extremely weakly binds to PSD-95, PSD95, and PDZ7 domain of GRIP.
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|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $578 | In stock | |
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| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NSC 668036 is a specific inhibitor of the Dishevelled (Dvl) PDZ domain, extremely weakly binds to PSD-95, PSD95, and PDZ7 domain of GRIP.
NSC 668036 inhibits the signaling induced by Wnt3A and blocks Wnt signaling by interrupting the Fz-Dvl interaction.
NSC 668036 suppresses β-catenin-driven gene transcription and abolishes TGF-β1-induced migration, expression of collagen I and α-α-SMA in fibroblasts.
NSC 668036 depresses fibrotic process in vivo.
| M.Wt | 460.52 | |
| Formula | C21H36N2O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester |
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1. Shan J, et al. Biochemistry. 2005 Nov 29;44(47):15495-503.
2. Wang C, et al. Exp Cell Res. 2015 Feb 1;331(1):115-22.
3. Chen X, et al. J Mol Model. 2009 Jan;15(1):91-6.
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