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Chemical Structure : NSC697923
CAS No.: 343351-67-7
Catalog No.: PC-35686Not For Human Use, Lab Use Only.
NSC697923 (NSC 697923) is a small molecule that specifically inhibits the activity of the ubiquitin-conjugating (E2) enzyme Ubc13 (UBE2N)-Uev1A.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 100 mg | $378 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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NSC697923 (NSC 697923) is a small molecule that specifically inhibits the activity of the ubiquitin-conjugating (E2) enzyme Ubc13 (UBE2N)-Uev1A.
NSC697923 impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-κB activity in ABC-DLBCL cells, inhibits NF-κB activation induced by PMA, but not by TNFα.
NSC697923 specifically inhibits Ubc13-mediated polyubiquitin chain synthesis in vitro, does not inhibits UbcH5c-mediated polyubiquitin chain formation.
NSC697923 inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells.
| M.Wt | 267.255 | |
| Formula | C11H9NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-nitro-5-tosylfuran |
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1. Pulvino M, et al. Blood. 2012 Aug 23;120(8):1668-77.
2. Cheng J, et al. Cell Death Dis. 2014 Feb 20;5:e1079.
3. Ritorto MS, et al. Nat Commun. 2014 Aug 27;5:4763.
4. Hodge CD, et al. ACS Chem Biol. 2015 Jul 17;10(7):1718-28.
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