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Chemical Structure : NSC 745887
Catalog No.: PC-63230Not For Human Use, Lab Use Only.
NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways.
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NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways.
NSC 745887 increases the sub-G1 population in dose- and time-dependent manners in GBM cells, increases expression of γH2AX and causes DNA fragmentation leading to DNA damage.
NSC 745887 suppresses the [18F]-FDG-specific uptake value in brain tumors.
| M.Wt | 260.252 | |
| Formula | C16H8N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fann LY, et al. Oncotarget. 2017 Dec 27;9(15):11922-11937.
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