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Chemical Structure : NVP-BKM120
CAS No.: 944396-07-0
Catalog No.: PC-45950Not For Human Use, Lab Use Only.
NVP-BKM120 (BKM-120, Buparlisib) is a potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $108 | In stock | |
| 100 mg | $178 | In stock | |
| 200 mg | $298 | In stock | |
| 1 g | Get quote |
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NVP-BKM120 (BKM-120, Buparlisib) is a potent, selective, orally bioavailable inhibitor of class I PI3K isoforms with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/β/δ/γ, respectively.
NVP-BKM120 (BKM-120, Buparlisib) much less effectively inhibits the class III PI3K Vps34 and mTOR, and has no effect on PI4Kβ and several other kinases.
NVP-BKM120 (BKM-120, Buparlisib) prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo.
| M.Wt | 410.3936 | |
| Formula | C18H21F3N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyridinamine, 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)- |
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1. Maira SM, et al. Mol Cancer Ther. 2012 Feb;11(2):317-28.
2. Pei Y, et al. Cancer Cell. 2012 Feb 14;21(2):155-67.
3. Koul D, et al. Clin Cancer Res. 2012 Jan 1;18(1):184-95.
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