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Chemical Structure : Necrosulfonamide
CAS No.: 1360614-48-7
Catalog No.: PC-42202Not For Human Use, Lab Use Only.
Necrosulfonamide is a small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation.
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|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
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Necrosulfonamide is a small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation.
Necrosulfonamide binds within the N-terminal 178 residues of human MLKL.
Necrosulfonamide arrests necrosis at a specific step at which RIP3 formed discrete punctae in cells.
| M.Wt | 461.4716 | |
| Formula | C18H15N5O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E)- |
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1. Sun L, et al. Cell. 2012 Jan 20;148(1-2):213-27.
2. Mulay SR, et al. Nat Commun. 2016 Jan 28;7:10274.
3. Chen S, et al. Apoptosis. 2017 May;22(5):626-638.
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