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Nelfinavir

Chemical Structure : Nelfinavir

CAS No.: 159989-64-7

Nelfinavir (AG-1343)

Catalog No.: PC-44303Not For Human Use, Lab Use Only.

A potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM.

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Biological Activity

A potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM; exhibits an antiviral EC50 of 30 nM in HIV-1 strain RF-infected CEM-SS cells; also inhibits the proliferation of NSCLC cells, as well as every cell line in the NCI60 cell line panel with mean GI50 of 5.2 uM, induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.

HIV Infection

Approved

Physicochemical Properties

M.Wt 567.784
Formula C32H45N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Zhang KE, et al. Antimicrob Agents Chemother. 2001 Apr;45(4):1086-93.

2. Shetty BV, et al. Antimicrob Agents Chemother. 1996 Jan;40(1):110-4.

3. Gills JJ, et al. Clin Cancer Res. 2007 Sep 1;13(17):5183-94.

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