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Chemical Structure : Netarsudil dihydrochloride
Catalog No.: PC-62716Not For Human Use, Lab Use Only.
Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2.
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Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2; 11 kinases are inhibited >90% in a panel of 422 kinases, only ROCK1 and ROCK2 (each 93% inhibition) and PKC (delta, 91%, and eta, 93% inhibition); exhibts improved bioavailability, demonstrates an effective and sustained IOP reduction for 24h after dosing; a novel ocular hypotensive agent for the treatment of Gglaucoma.
Other Indication
Approved
| M.Wt | 526.45 | |
| Formula | C28H29Cl2N3O3 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Sturdivant JM, et al. Bioorg Med Chem Lett. 2016 May 15;26(10):2475-80.
2. Li G, et al. Eur J Pharmacol. 2016 Sep 15;787:20-31.
3. Lin CW, et al. J Ocul Pharmacol Ther. 2017 Jun 13. doi: 10.1089/jop.2017.0023.
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