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Chemical Structure : ONO-5334
Catalog No.: PC-61421Not For Human Use, Lab Use Only.
ONO-5334 is a potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively.
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ONO-5334 is a potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively.
ONO-5334 shows less or no potentcy for human cathepsin S/L/B/C (Ki=0.83/1.7/32/2500 nM).
ONO-5334 inhibits human osteoclasts bone resorption in vitro at a concentration more than 100 fold lower than that of alendronate.
ONO-5334 reduces plasma calcium level increased by PTHrP in thyroparathyroidectomized rats, decreases serum and urine C-telopeptide of type I collagen level.
ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with EC50 of 500 nM.
| M.Wt | 438.59 | |
| Formula | C21H34N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ochi Y, et al. Bone. 2011 Dec;49(6):1351-6.
2. Ochi Y, et al. Bone. 2014 Aug;65:1-8. doi: 10.1016/j.bone.2014.04.023.
3. Ochi Y, et al. J Bone Miner Metab. 2014 Nov;32(6):645-52.
4. Nagase S, et al. Br J Clin Pharmacol. 2012 Dec;74(6):959-70.
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