Chemical Structure : OSU-T315
CAS No.: 1333146-24-9
Catalog No.: PC-45519Not For Human Use, Lab Use Only.
A novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM.
Packing | Price | Stock | Quantity |
---|---|---|---|
5 mg | $280 | In stock | |
10 mg | $400 | In stock | |
50 mg | $1200 | In stock |
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A novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM; exhibits high in vitro potency against a panel of prostate and breast cancer cell lines (IC50=1-2.5 uM) with no effect on normal epithelial cells; facilitates the dephosphorylation of Akt at Ser-473 and other ILK targets, including GSK-3β and myosin light chain; suppresses the expression of the transcription/translation factor YB-1 and HER2, EGFR in PC-3 cells, induces autophagy and apoptosis; demonstrates in vivo efficacy in suppressing PC-3 xenograft tumor growth; orally active.
M.Wt | 533.5873 | |
Formula | C30H30F3N5O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
1H-Pyrazole-3-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]- |
1. Lee SL, et al. J Med Chem. 2011 Sep 22;54(18):6364-74.
2. Liu TM, et al. Blood. 2015 Jan 8;125(2):284-95.
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