Chemical Structure : PD-146176
Catalog No.: PC-70225Not For Human Use, Lab Use Only.
A potent, selective, non-competitve inhibitor of 15-lipoxygenase (15-LOX) with Ki of 197 nM.
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A potent, selective, non-competitve inhibitor of 15-lipoxygenase (15-LOX) with Ki of 197 nM; shows no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2; significantly abrogates SAT1-induced ferroptosis, inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP.
Atherosclerosis
Discontinued
M.Wt | 237.3 | |
Formula | C15H11NS | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Ou YProc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6806-E6812., et al.
2. Bocan TM, et al. Atherosclerosis. 1998 Feb;136(2):203-16.
3. Sendobry SM, et al. Br J Pharmacol. 1997 Apr;120(7):1199-206.
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