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Chemical Structure : PD 404182
CAS No.: 72596-74-8
Catalog No.: PC-60661Not For Human Use, Lab Use Only.
PD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $168 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | $758 | In stock | |
| 100 mg | Get quote |
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PD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels.
PD 404182 significantly increases intracellular levels of ADMA and reduces LPS-induced NO production in cultured primary human vascular endothelial cells (ECs).
PD 404182 abrogates the formation of tube-like structures by ECs in in vitro angiogenesis assay.
PD 404182 also shows anti-HIV and anti-HSV activites.
| M.Wt | 217.29 | |
| Formula | C11H11N3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine |
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1. Ghebremariam YT, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76.
2. Mizuhara T, et al. Bioorg Med Chem. 2013 Apr 1;21(7):2079-87.
3. Ghebremariam YT, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76.
4. Chamoun-Emanuelli AM, et al. Antimicrob Agents Chemother. 2014;58(2):687-97.
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