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Chemical Structure : PE859
Catalog No.: PC-43143Not For Human Use, Lab Use Only.
PE859 is a novel, orally active tau aggregation inhibitor that inhibits the heparin-induced aggregation of both 3RMBD and full length tau with IC50 of 0.81 uM and 2.23 uM, respectively.
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PE859 is a novel, orally active tau aggregation inhibitor that inhibits the heparin-induced aggregation of both 3RMBD and full length tau with IC50 of 0.81 uM and 2.23 uM, respectively; also inhibits amyloid β (Aβ) aggregation with IC50 of 1.2 uM; significantly reduces sarkosyl-insoluble aggregated tau along with the prevention of onset and progression of the motor dysfunction in JNPL3 P301L-mutated human tau transgenic mice.
| M.Wt | 448.5157 | |
| Formula | C28H24N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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1. Okuda M, et al. PLoS One. 2015 Feb 6;10(2):e0117511.
2. Okuda M, et al. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5024-5028.
3. Okuda M, et al. J Alzheimers Dis. 2017;59(1):313-328.
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