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Chemical Structure : PF-04136309
CAS No.: 1341224-83-6
Catalog No.: PC-61557Not For Human Use, Lab Use Only.
PF-4136309 (INCB8761) is a potent, selective, competitive, reversible full CCR2 antagonist with IC50 of 2-5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $135 | In stock | |
| 25 mg | $385 | In stock | |
| 100 mg | $985 | In stock | |
| 500 mg | Get quote |
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PF-4136309 (INCB8761) is a potent, selective, competitive, reversible full CCR2 antagonist with IC50 of 2-5 nM.
PF-4136309 (INCB8761) depletes inflammatory monocytes and macrophages from the primary tumor and premetastatic liver resulting in enhanced antitumor immunity, decreased tumor growth, and reduced metastasis.
| M.Wt | 568.59 | |
| Formula | C29H31F3N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide |
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1. Sanford DE, et al. Clin Cancer Res. 2013 Jul 1;19(13):3404-15.
2. Nywening TM, et al. Lancet Oncol. 2016 May;17(5):651-62.
3. Xue CB, et al. ACS Med Chem Lett. 2011 Oct 5;2(12):913-8.
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