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Chemical Structure : PF-04895162
Catalog No.: PC-36142Not For Human Use, Lab Use Only.
PF-04895162 (ICA-105665, PF 4895162) is an orally available agonist of neuronal Kv7 potassium channel, opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels, also known as KCNQ2/3 and KCNQ3/5 channels.
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PF-04895162 (ICA-105665, PF 4895162) is an orally available agonist of neuronal Kv7 potassium channel, opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels, also known as KCNQ2/3 and KCNQ3/5 channels.
PF-04895162 (ICA-105665 has demonstrated broad spectrum antiseizure activity in multiple animal models including maximal electroshock, 6 Hz seizures, pentylenetetrazole, and electrical kindling at doses from <1 to 5 mg/kg.
| M.Wt | 355.345 | |
| Formula | C19H15F2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kasteleijn-Nolst Trenité DG, et al. Epilepsia. 2013 Aug;54(8):1437-43.
2. Aleo MD, et al. Pharmacol Res Perspect. 2019 Feb;7(1):e00467.
3. Bialer M, et al. Epilepsy Res. 2013 Jan;103(1):2-30.
4. Roeloffs R, et al. J Pharmacol Exp Ther. 2008 Sep;326(3):818-28.
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