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Chemical Structure : PF-06426779
Catalog No.: PC-35553Not For Human Use, Lab Use Only.
PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM.
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PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM.
PF-06426779 displays excellent selectivity against the human kinome, and >100-fold selectivity for IRAK4 over IRAK1.
| M.Wt | 347.346 | |
| Formula | C17H18FN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. De Nardo D, et al. J Biol Chem. 2018 Aug 3. pii: jbc.RA118.003314.
2. Lee KL, et al. J Med Chem. 2017 Jul 13;60(13):5521-5542.
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