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Chemical Structure : PF-06855800
Catalog No.: PC-35520Not For Human Use, Lab Use Only.
PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM.
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PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM.
PF-06855800 demonstrates antiproliferative activity in Z-138 cancer cells with IC50 of 1 nM,
PF-06855800 also shows anti-tumor activity in Z-138 mice xenograft models.
| M.Wt | 392.811 | |
| Formula | C19H18ClFN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Indrawan J. Mcalpine, et al. Abstract 4857: Discovery of PF-06855800, a SAM competitive PRMT5 inhibitor with potent antitumor activity. DOI: 10.1158/1538-7445.AM2018-4857. AACR 2018.
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