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Chemical Structure : PF-DcpSi
Catalog No.: PC-60223Not For Human Use, Lab Use Only.
A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM.
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A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM; shows no significant activity for DHFR (IC50>30 uM); has in vivo mouse CNS PK profile, shows activity in SMA mouse model by prolonging survival and improving function thereby ruling out lysosomotropism.
Spinal Muscular Atrophy (SMA)
Preclinical
| M.Wt | 309.304 | |
| Formula | C16H12FN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. J Med Chem. 2017 Apr 13;60(7):3094-3108.
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