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Chemical Structure : PT-2399
Catalog No.: PC-60317Not For Human Use, Lab Use Only.
PT-2399 (PT 2399, PT2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain.
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PT-2399 (PT 2399, PT2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain; minimally affects a panel of 68 receptors, ion channels, and enzymes; specifically disassembles HIF-2 but not HIF-1 complexes, reduces the expression of HIF-2 target genes (VEGF, SERPINE1, IGFBP3, CCND1, TGFA, and SLC2A1), but not HIF-1 targets (CA9, PGK1, and LDHA); exhibits tumor growth inhibition in selected VHL-deficient clear-cell renal cell carcinoma (ccRCC) models.
| M.Wt | 419.32 | |
| Formula | C17H10F5NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen W, et al. Nature. 2016 Nov 3;539(7627):112-117.
2. Cho H, et al. Nature. 2016 Nov 3;539(7627):107-111.
3. Ricketts CJ, et al. Cancer Cell. 2016 Oct 10;30(4):515-517.
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