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Chemical Structure : PTC-596
CAS No.: 1610964-64-1
Catalog No.: PC-60486Not For Human Use, Lab Use Only.
PTC-596 (Unesbulin, PTC596) is a novel, orally active, small molecule inhibitor of BMI-1 that accelerates BMI-1 degradation, inhibits AML cells growth with IC50 of <100 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PTC-596 (Unesbulin, PTC596) is a novel, orally active, small molecule inhibitor of BMI-1 that accelerates BMI-1 degradation, inhibits AML cells growth with IC50 of <100 nM.
PTC-596 is a direct microtubule polymerization inhibitor.
PTC-596 reduces total BMI-1 protein levels by 87% and 61% in MOLM-13 and OCI-AML3 cells at 100 nM, induces apoptosis and reduces the levels of ubiquitylated histone H2A.
PTC-596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.
| M.Wt | 420.347 | |
| Formula | C19H13F5N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-fluoro-2-(6-fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine |
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1. Nishida Y, et al. Blood Cancer J. 2017 Feb 17;7(2):e527.
2, Eberle-Singh JA, et al. Clin Cancer Res. 2019 Jun 7. pii: clincanres.3281.2018. doi: 10.1158/1078-0432.CCR-18-3281.
3, Maeda A, et al. Oncotarget. 2018 Jun 19;9(47):28547-28560.
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