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Chemical Structure : PYZD-4409
CAS No.: 423148-78-1
Catalog No.: PC-43475Not For Human Use, Lab Use Only.
PYZD-4409 is a specific inhibitor of ubiquitin-activating enzyme UBA1 with IC50 of 20 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PYZD-4409 is a specific inhibitor of ubiquitin-activating enzyme UBA1 with IC50 of 20 uM.
PYZD-4409 inhibits the ATP-dependent activation of ubiquitin and subsequent transfer of the activated ubiquitin from the E1 to the common human E2 enzyme UBE2E2.
PYZD-4409 blockes the E1-dependent conjugation of ubiquitin to the E2 enzyme cdc3, induces cell death in hematologic malignant cell lines and primary patient samples preferentially over normal hematopoietic cells.
PYZD-4409 decreases tumor weight and volume without untoward toxicity in vivo.
| M.Wt | 351.67 | |
| Formula | C14H7ClFN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
3,5-Pyrazolidinedione, 1-(3-chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]- |
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1. Xu GW, et al. Blood. 2010 Mar 18;115(11):2251-9.
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