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Chemical Structure : PZ09
Catalog No.: PC-36023Not For Human Use, Lab Use Only.
PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold).
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PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold).
PZ09 also shows high selectivity for CDK-2 (>200-fold), as well as a broader range of other kinases (<50% inhibition at 10 uM).
PZ09 is a small-molecule inhibitor, the first tool to successfully interrogate aPKC signaling in cells.
| M.Wt | 423.524 | |
| Formula | C25H25N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Trujillo JI, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):908-11.
2. Kajimoto T, et al. Sci Signal. 2019 Jan 1;12(562). pii: eaat6662. doi: 10.1126/scisignal.aat6662.
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