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Chemical Structure : Pelitinib
CAS No.: 257933-82-7
Catalog No.: PC-45812Not For Human Use, Lab Use Only.
Pelitinib (EKB-569, WAY-EKB 569) is a potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 100 mg | $398 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Pelitinib (EKB-569, WAY-EKB 569) is a potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM.
Pelitinib (EKB-569, WAY-EKB 569) inhibits autophosphorylation of the cytoplasmic domain of HER-2 with IC50 of 1.23 uM.
Pelitinib (EKB-569, WAY-EKB 569) shows 1-3 orders of magnitude higher IC50 value for Src, Cdk4, c-Met, Raf, and MEK/ERK.
Pelitinib (EKB-569, WAY-EKB 569) inhibits proliferation in NHEK, A431, and MDA-468 cells (IC50= 61, 125, and 260 nM, respectively).
Pelitinib (EKB-569, WAY-EKB 569) potently inhibits the EGFR phosphorylation in A431 xenografts, suppresses tumorigenesis in APCMin/+ mice.
| M.Wt | 467.9231 | |
| Formula | C24H23ClFN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 16 mg/mL |
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| Chemical Name/SMILES |
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)- |
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1. Wissner A, et al. J Med Chem. 2003 Jan 2;46(1):49-63.
2. Nunes M, et al. Mol Cancer Ther. 2004 Jan;3(1):21-7.
3. Torrance CJ, et al. Nat Med. 2000 Sep;6(9):1024-8.
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