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Chemical Structure : Pemetrexed disodium
CAS No.: 150399-23-8
Catalog No.: PC-42710Not For Human Use, Lab Use Only.
A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $56 | In stock | |
| 500 mg | $135 | In stock |
Bulk size, bulk discount!
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A classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively; increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma.
Chemotherapeutic Agents
Approved
| M.Wt | 471.3743 | |
| Formula | C20H19N5Na2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: 11.19 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt (1:2) |
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1. Shih C, et al. Cancer Res. 1997 Mar 15;57(6):1116-23.
2. Tonkinson JL, et al. Cancer Res. 1999 Aug 1;59(15):3671-6.
3. Curtin NJ, et al. Lancet Oncol. 2001 May;2(5):298-306.
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