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Chemical Structure : Pexacerfont
CAS No.: 459856-18-9
Catalog No.: PC-61269Not For Human Use, Lab Use Only.
Pexacerfont (BMS562086, DPC-A69448) is a potent, selective and orally active CRF1 receptor antagonist with IC50 of 6.1 nM, >1,000-fold selectivity over CRF-binding protein and biogenic amine receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Pexacerfont (BMS562086, DPC-A69448) is a potent, selective and orally active CRF1 receptor antagonist with IC50 of 6.1 nM, >1,000-fold selectivity over CRF-binding protein and biogenic amine receptors.
Pexacerfont (BMS562086, DPC-A69448) demonstrates oral effectivity in rat models of anxiety, possesses good pharmacokinetic profile in vivo.
| M.Wt | 340.431 | |
| Formula | C18H24N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine |
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1. Kwako LE, et al. Neuropsychopharmacology. 2015 Mar 13;40(5):1053-63.
2. Gilligan PJ, et al. J Med Chem. 2009 May 14;52(9):3084-92.
3. Schwandt ML, et al. Neuropsychopharmacology. 2016 Nov;41(12):2818-2829.
4. Zhou L, et al. Drug Metab Dispos. 2012 Jun;40(6):1093-103.
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